Heat therapy uses heat to improve the effects of chemotherapy agents. In hyperthermic chemotherapy, agents such as cisplatin or doxorubicin are heated and injected at temperatures as high as 109° F, because tumor cells are more susceptible to the toxic effects of the drugs at higher temperatures. In an early study, patients with malignant mesothelioma showed good tolerance to hyperthermic cisplatin given into the pleural space.
In chemohyperthermia, the pleural cavity is heated before chemotherapy is given directly into it. Although proved safe, it has not demonstrated improved survival.
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